Most annoying things in video games

[The Stars]

When the difficulty settings basically only increase HP and Damage of the enemy without having something interesting in return... We already get you're attack patterns; you just don't DIE XD.

[The Wandering Magus]

when the graphics show all sorts of things falling apart, but your character just keeps walking along like nothing's wrong.

[PrincessButton]

Running out of stamina

[The Wandering Magus]

running out of ANYTHING

[super_chris85]

when you can't hear a fluffing word a character is saying with subtitles off

[Book Smarts]

Running out of stamina

Morrowind's stamina system

[The Wandering Magus]

stacking debuffs

[Bravo 658]

When everypony in Skyrim panics at the thought of a dragon, but the guards effortlessly tear one to shreds when it tries to attack one of their towns.

[The Wandering Magus]

when the guards are rediculously effective at destroying anything when there ISN'T a quest, but as soon as you start the quest they're weak cowards.

[Dark Hooves]

having nopony to play with

[Sea Foam]

that one line of dialog you seem to skip or goes by to quick but then doent repeat itself so you get yourself lost just trying to work out where your going or what your doing

I once played a point and click adventure game where they gave me a phone number that I needed to progress. (In game phone, of course) However, I neglected to write it down because I assumed the game would be generous enough to do that for me. Needless to say, I was wrong and was forced to re-play the entire game for the one phone number. 

[The Wandering Magus]

when you point and click and click the wrong enemy...

[wantamint7]

Not sure if this was said but playing a game where you manually save but save at a point where you immediately die.

[The Wandering Magus]

dying and losing everything in your inventory even if you saved

[ComputerDeathglare]

Completely ruining the game because you decided to explore.

[The Wandering Magus]

lag...

[ComputerDeathglare]

CHEATERS!!

[Dark Hooves]

the don't throw grenades mod in Halo multi-player

[The Wandering Magus]

accidentally blowing yourself up...

[HerpyDooves]

Unresponsive admins.